Whole Genome Sequencing
Comprehensive analysis of your entire ~3 billion base pair genome — the most complete genetic test available.
Optimal Range
Identification of pathogenic variants and risk alleles
Why It Matters
WGS identifies inherited risks for cancer (BRCA1/2, Lynch syndrome), heart disease (familial hypercholesterolemia), and neurodegenerative conditions. It also reveals longevity-associated variants in genes like FOXO3 and SIRT1, enabling truly personalized prevention.
Understanding Whole Genome Sequencing
Whole genome sequencing (WGS) reads the complete sequence of your DNA — all 3.2 billion base pairs across your 23 pairs of chromosomes, including both protein-coding regions (exons, ~1.5% of the genome) and non-coding regions (introns, regulatory elements, and intergenic DNA). This is the most comprehensive genetic test available and provides a permanent, reanalyzable record of your genetic blueprint.
The clinical utility of WGS spans multiple categories. High-penetrance pathogenic variants in genes like BRCA1/BRCA2 (breast and ovarian cancer risk), MLH1/MSH2 (Lynch syndrome/hereditary colorectal cancer), LDLR (familial hypercholesterolemia), and MYBPC3/MYH7 (hypertrophic cardiomyopathy) can be identified and acted upon through enhanced screening, prophylactic interventions, or targeted treatments. Moderate-risk variants and polygenic risk scores can further refine your risk profile for common conditions like coronary artery disease, type 2 diabetes, and atrial fibrillation.
WGS also reveals longevity-relevant variants. Variations in FOXO3, APOE, CETP, and TERT have been associated with exceptional longevity. Pharmacogenomic variants (CYP450 enzymes) inform medication selection and dosing. Carrier status for recessive conditions (cystic fibrosis, sickle cell trait, Tay-Sachs) is relevant for family planning. Because your genome does not change, WGS is a one-time investment that becomes more valuable over time as scientific understanding of genetic variants expands — your raw data can be reanalyzed as new discoveries are made.