Back to all biomarkers
Genetic
MTHFR Variants
Methylenetetrahydrofolate reductase gene variants — affect folate metabolism and methylation capacity.
Optimal Range
Wild type (no variants) · C677T/A1298C variants are common
Why It Matters
MTHFR variants (present in ~40% of the population) reduce the enzyme's efficiency, impairing methylation — a critical process for DNA repair, detoxification, and neurotransmitter production. Methylfolate supplementation can compensate.